The Prince of Wales Stakes is Fort Erie's most important annual event. It was first run in 1929 but achieved its current prominence in 1959 when E.P. Taylor made it the second leg of the Canadian Triple Crown. Among the winners of the Prince of Wales are New Providence, With Approval, Dance Smartly, Peteski and Wando.
The Puss N Boots Cup is run annually at the start of the fall meeting. It is named after the horse Puss N Boots, who was leading in the Vandal Stakes (then run at Fort Erie) when he decided to jump the inner hedge near the finish line. The horse landed in one of the infield ponds, dumping his jockey in the process. In recognition, the winning jockey of the Cup jumps into the pond in celebration.
A number of other stakes races were once run at Fort Erie but have since been transferred to Woodbine. This includes the Bison City Stakes, the second leg of the Canadian Triple Tiara for fillies. Northern Dancer won the Summer Stakes in 1963 when it was still run at Fort Erie.
Dachshund racing was added to the track's schedule in 2018; the success of the first race held that year led to the addition of a basset hound race for 2019.